Calculation Formulas of Scoring System: The Sokal, Hasford, EUTOS and ELTS Scores

Calculation Formulas of Scoring System of survival in chronic myeloid leukemia (CML): The Sokal, Hasford, EUTOS and ELTS Scores.

Sokal scoreExp 0.01 16 x (age – 43.4) + 0.0345 x (spleen – 7.51) + 0.1880 x [(platelet count/700)2-0.563] + 0.0887 x (blasts -2.10)Low risk: <0.8
Intermediate risk: 0.8-1.2
High risk: >1.2
Hasford score(0.6666 x age [0 when age <50 years; 1, otherwise] + 0.0420 x spleen + 0.0584 x blasts + 0.0413 x eosinophils + 0.2039 x basophils [0 when basophils <3%; 1, otherwise] + 1.0956 x platelet count [0 when platelets <1500 x I09/L; 1, otherwise]) x 1000Low risk: ≤780
Intermediate risk: 781-1480
High risk: >1480
EUTOS score(Basophils x 7) + (spleen x 4)Low risk: ≤87
High risk: >87
ELTS score0.0025 x (age/10)3 + 0.0615 x spleen + 0.1052 x blasts + 0.4104 x (platelet count/1000)-05Low risk: ≤1.5680
Intermediate risk: 1.5680-2.2185
High risk: >2.2185

Note: Exp – exponential function; Age is in years; Spleen is in cm below the costal margin; Platelet count is in * I09/L; Blasts, eosinophils and basophils are in percent of peripheral blood.
EUTOS, European Treatment and Outcome Study; ELTS, EUTOS long-term survival.

A source:
Sokal JE, Cox EB, Baccarani M, Tura S, Gomez GA, Robertson JE et al. Prognostic discrimination in “good-risk” chronic granulocytic leukemia. Blood 1984; 63: 789-99.
Thomas M, Irving J, Lennard A, Proctor S, Taylor P. Validation of the Hasford score in a demographic study in chronic granulocytic leukaemia. Journal of Clinical Pathology. 2001;54(6):491-493. doi:10.1136/jcp.54.6.491.
Uz B, Buyukasik Y, Atay H, et al. EUTOS CML prognostic scoring system predicts ELN-based ‘event-free survival’ better than Euro/Hasford and Sokal systems in CML patients receiving front-line imatinib mesylate. Hematology. 2013;18(5):247-52.
Yahng SA, Jang EJ, Choi SY, et al. Comparison of Sokal, Hasford and EUTOS scores in terms of long-term treatment outcome according to the risks in each prognostic model: a single center data analyzed in 255 early chronic phase chronic myeloid leukemia patients treated with frontline imatinib mesylate. Blood 2012;120:Abstract 2794.
Marin D, Ibrahim AR, Goldman JM. European Treatment and Outcome Study (EUTOS) score for chronic myeloid leukemia still requires more confirmation. J Clin Oncol 2011;29:3944–5.
Yamamoto E, Fujisawa S, Hagihara M, et al. European Treatment and Outcome Study score does not predict imatinib treatment response and outcome in chronic myeloid leukemia patients. Cancer Sci. 2014;105(1):105-9.
Pfirrmann M, Baccarani M, Saussele S, et al. Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia. Leukemia. 2016;30(1):48-56. 
Validation of the EUTOS Long-Term Survival Score in Chinese Chronic Myeloid Leukemia Patients Treated with Imatinib: A Multicenter Real-World Study DOI:10.2147/CMAR.S237467
Pfirrmann M, Baccarani M, Saussele S, Guilhot J, Cervantes F, Ossenkoppele G, Hoffmann V S, Castagnetti F, Hasford J, Hehlmann R, Simonsson B. Prognosis of long-term survival considering disease-specific death in patients with chronic myeloid leukemia. Leukemia 2015. Article in press.
Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst. 1998; 90: 850-8.

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