Baseline Cardiovascular Risk Assessment in Cancer Patients Scheduled to Receive Cardiotoxic Cancer Therapies (Anthracycline Chemotherapy) – Online Calculator

Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies (Anthracycline Chemotherapy) from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society (HFA-ICOS).

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Previous cardiovascular disease

Cardiac biomarkers (where available)

Demographic and cardiovascular risk factors

Previous cardiotoxic cancer treatment

Lifestyle risk factors


BMI, body mass index; BNP, brain natriuretic peptide; CABG, coronary artery bypass graft; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-brain natriuretic peptide; PCI, percutaneous coronary intervention
a Elevated above the upper limit of normal for local laboratory reference range.
b Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg, or on treatment.
c Glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment.
d Estimated glomerular filtration rate <60 mL/min/1.73 m2.

* Required


Risk factorsScoreLevel of
evidence
Previous cardiovascular disease
Heart failure or cardiomyopathyVery highB
Severe valvular heart diseaseHighC
Myocardial infraction or previous coronary revascularization (PCI or CABG)HighC
Stable anginaHighC
Baseline LVEF <50%HighB
Borderline LVEF 50-54%Medium2C
Cardiac biomarkers
(where available)
Elevated baseline troponinMedium1C
Elevated baseline BNP or NT-proBNPMedium1C
Demographic and cardiovascular risk factors
Age ≥80 yearsHighB
Age 65–79 yearsMedium2B
HypertensionMedium1B
Diabetes mellitusMedium1C
Chronic kidney diseaseMedium1C
Previous cardiotoxic cancer treatment
Previous anthracycline exposureHighB
Prior radiotherapy to left chest or mediastinumHighC
Previous non-anthracycline-based chemotherapyMedium1C
Lifestyle risk factors
Current smoker or significant smoking historyMedium1C
Obesity (BMI >30 kg/m2)Medium1C
BMI, body mass index; BNP, brain natriuretic peptide; CABG, coronary artery bypass graft; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-brain natriuretic peptide; PCI, percutaneous coronary intervention
a Elevated above the upper limit of normal for local laboratory reference range.
b Systolic blood pressure >140 mmHg or diastolic blood pressure >90 mmHg, or on treatment.
c Glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment.
d Estimated glomerular filtration rate <60 mL/min/1.73 m2.


HFA-ICOS risk assessment

no risk factor OR one medium1 risk factorLow risk<2%
medium risk factors with a total of 2–4 pointsMedium risk2-9%
medium risk factors with a total of ≥5 points OR any high risk factorHigh risk10-19%
any very high risk factorVery high risk>20%


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Charlson Comorbidity Index (CCI) Online Calculator

Charlson Comorbidity Index predicts 10-year survival in patients with multiple comorbidities.

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History of definite or probable MI (EKG changes and/or enzyme changes)

Exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics, or afterload reducing agents

Intermittent claudication or past bypass for chronic arterial insufficiency, history of gangrene or acute arterial insufficiency, or untreated thoracic or abdominal aneurysm (≥6 cm)

History of a cerebrovascular accident with minor or no residua and transient ischemic attacks

Chronic cognitive deficit

Any history of treatment for ulcer disease or history of ulcer bleeding

Severe = cirrhosis and portal hypertension with variceal bleeding history, moderate = cirrhosis and portal hypertension but no variceal bleeding history, mild = chronic hepatitis (or cirrhosis without portal hypertension)

Severe = on dialysis, status post kidney transplant, uremia, moderate = creatinine >3 mg/dL (0.27 mmol/L)


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Multiple Myeloma Diagnostic Criteria – Online Calculator

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≥1 of the following (A or B)

≥1 myeloma defining event (C1 or C2)


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For Multiple Myeloma Diagnostic Criteria assessment necessary to provide selection of the…
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