Sokal, Hasford, and EUTOS scores were developed at different times in the treatment of chronic myeloid leukemia (CML). Hasford score is a prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Interferon alfa is a conservative and widely used alternative to bone marrow transplantation in treatment of patients with early chronic myeloid leukemia before tyrosine kinase inhibitors implementation in clinical practice. 

0.666 when age ≥50 years + (0.042 x spleen) + 1.0956 when platelet count > 1500 x10⁹/l + (0.0584 x blasts cells) + 0.20399 when basophils  > 3% + (0.0413 x eosinophils)x100

• Age in years
• Spleen is in cm below the costal margin
• Blast cells, eosinophils and basophils are in percent of peripheral blood differential.

Hasford score

• ≤ 780 – Low risk
• 781-1480 – Intermediate risk
• ≥1480 – High risk 

A source:
Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst. 1998; 90: 850-8.

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Multiple Myeloma Diagnostic Criteria – Online Calculator

February 5, 2023

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Date of assessment

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≥1 of the following (A or B)

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A. Clonal bone marrow plasma cells ≥10%

B. Biopsy-proven bony or extramedullary plasmacytoma

≥1 myeloma defining event (C1 or C2)

• C1. End organ damage attributable to underlying plasma cell disorder (≥1 of the following): *

o Hypercalcemia (Serum calcium >1 mg/dL (>0.25 mmol/L) higher than upper limit of normal or >11 mg/dL (>2.75 mmol/L))

o Renal insufficiency (Creatinine clearance<40 mL per min or serum creatinine >2 mg/dL (177 μmol/L))

o Anemia (Hemoglobin >2 g/dL (20 g/L) below lower limit of normal

o Bone lesions (≥1 osteolytic lesion on skeletal x-ray

• C2. ≥1 of the following biomarkers of malignancy: *

o Clonal bone marrow plasma cells ≥60%

o Involved:uninvolved sFLC ratio ≥100

o >1 focal lesion on MRI

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Result

Diagnostic result Negative. Not positive for multiple myeloma by IMWG criteria

Diagnostic result Positive for multiple myeloma by IMWG criteria

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