Sokal, Hasford, and EUTOS scores were developed at different times in the treatment of chronic myeloid leukemia (CML). Hasford score is a prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. Interferon alfa is a conservative and widely used alternative to bone marrow transplantation in treatment of patients with early chronic myeloid leukemia before tyrosine kinase inhibitors implementation in clinical practice.
Maximum distance palpable below costal margin:
|Patient’s Hasford score||Hasford score range||Hasford risk group|
0.666 when age ≥50 years + (0.042 x spleen) + 1.0956 when platelet count > 1500 x109/l + (0.0584 x blasts cells) + 0.20399 when basophils > 3% + (0.0413 x eosinophils)x100
- Age in years
- Spleen is in cm below the costal margin
- Blast cells, eosinophils and basophils are in percent of peripheral blood differential.
- ≤ 780 – Low risk
- 781-1480 – Intermediate risk
- ≥1480 – High risk
Hasford J, Pfirrmann M, Hehlmann R, Allan NC, Baccarani M, Kluin-Nelemans JC et al. A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa. J Natl Cancer Inst. 1998; 90: 850-8.
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