IPSET – Thrombosis Risk for essential thrombocythemia: Online Calculator


International Prognostic Score of thrombosis in World Health Organization – essential thrombocythemia (IPSET-thrombosis).

IPSET-thrombosis model provides objective estimates of the probability of thrombotic events in patients with newly diagnosed ET.


(one or more of: hypertension, diabetes mellitus, active smoking)

Points 0
* Required

The scale consist of the following parameters, listed below:

Patient age 
• under 60 years0
• 60 years or older1
Prior thrombotic event2
Cardiovascular risk factors present
(One or more of: hypertension, diabetes mellitus, active smoking)
Detected JAK2 V617F mutation2

The primary objective of essential thrombocythemia (ET) management is to prevent thromboembolic complications. In this regard, advanced age and thrombosis history were used to assess this risk. More recently, JAK2V617F and cardiovascular (CV) risk factors were identified as additional modifiers, leading to the development of a 3-tiered International Prognostic Score of Thrombosis for ET (IPSET-thrombosis): “low”, “intermediate”, and “high”.

Total 6 points (Age 1, H/O Thrombosis 2, Cardiovascular risk factor 1 and JAK2V617F – 2 points).

Determine risk group and prognosis:

ScoreRisk categoryAnnual thrombosis risk
0 – 1Low1.03%
3 – 6High3.56%

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Subscribe to our pages:

Barbui T, Finazzi G, Carobbio A, Thiele J, Passamonti F, Rumi E et al. Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood 2012; 12: 5128-33

Charlson Comorbidity Index (CCI) Online Calculator

Charlson Comorbidity Index predicts 10-year survival in patients with multiple comorbidities.


History of definite or probable MI (EKG changes and/or enzyme changes)

Exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics, or afterload reducing agents

Intermittent claudication or past bypass for chronic arterial insufficiency, history of gangrene or acute arterial insufficiency, or untreated thoracic or abdominal aneurysm (≥6 cm)

History of a cerebrovascular accident with minor or no residua and transient ischemic attacks

Chronic cognitive deficit

Any history of treatment for ulcer disease or history of ulcer bleeding

Severe = cirrhosis and portal hypertension with variceal bleeding history, moderate = cirrhosis and portal hypertension but no variceal bleeding history, mild = chronic hepatitis (or cirrhosis without portal hypertension)

Severe = on dialysis, status post kidney transplant, uremia, moderate = creatinine >3 mg/dL (0.27 mmol/L)

* Required
VariablePointsAge <50…
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