IPSET – Thrombosis Risk for essential thrombocythemia: Online Calculator


International Prognostic Score of thrombosis in World Health Organization – essential thrombocythemia (IPSET-thrombosis).

IPSET-thrombosis model provides objective estimates of the probability of thrombotic events in patients with newly diagnosed ET.


(one or more of: hypertension, diabetes mellitus, active smoking)

Points 0
* Required

The scale consist of the following parameters, listed below:

Patient age 
• under 60 years0
• 60 years or older1
Prior thrombotic event2
Cardiovascular risk factors present
(One or more of: hypertension, diabetes mellitus, active smoking)
Detected JAK2 V617F mutation2

The primary objective of essential thrombocythemia (ET) management is to prevent thromboembolic complications. In this regard, advanced age and thrombosis history were used to assess this risk. More recently, JAK2V617F and cardiovascular (CV) risk factors were identified as additional modifiers, leading to the development of a 3-tiered International Prognostic Score of Thrombosis for ET (IPSET-thrombosis): “low”, “intermediate”, and “high”.

Total 6 points (Age 1, H/O Thrombosis 2, Cardiovascular risk factor 1 and JAK2V617F – 2 points).

Determine risk group and prognosis:

ScoreRisk categoryAnnual thrombosis risk
0 – 1Low1.03%
3 – 6High3.56%

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Barbui T, Finazzi G, Carobbio A, Thiele J, Passamonti F, Rumi E et al. Development and validation of an International Prognostic Score of thrombosis in World Health Organization-essential thrombocythemia (IPSET-thrombosis). Blood 2012; 12: 5128-33

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