IMPEDE VTE Score
IMPEDE score for venous thromboembolism risk stratification in patients with multiple myeloma receiving immunomodulators.
| Individual Risk Factors | Points | Myeloma risk scores | Points |
| Positive Factors | |||
| Central venous catheter/tunneled central catheter | +2 | Immunomodulator (IM) | +4 |
| Fracture of the pelvis, hip joint, or femur | +4 | A drug that stimulates erythropoiesis | +1 |
| Obesity (body mass index ≥ 25) | +1 | Dexamethasone < 160 mg per month | +2 |
| Previous VTE | +5 | Dexamethasone > 160 mg per month | +4 |
| Doxorubicin or multicomponent chemotherapy | +3 | ||
| Negative Factors | |||
| Ethnicity/Race – Mongoloid/Pacific Islander | -3 | ||
| Current thromboprophylaxis: low molecular weight heparin (LMWH) at prophylactic doses or aspirin | -3 | ||
| Current thromboprophylaxis: LMWH at prophylactic doses or warfarin | -4 |
Calculation
High risk (>3 points). An anticoagulant is recommended if it has not been prescribed before:
- Enoxaparin 40 mg subcutaneously 1 time/day
- Dalteparin 5000 units 1 time/day (category 2B)
- Warfarin (INR 2-3)
Low risk (≤3 points). Recommended:
- Do not prescribe medications
- Aspirin 81-325 mg/day
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