The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI)

Regional distribution or pattern:
Symmetric hip flexors or thigh aches
Symmetric calf aches
Symmetric upper proximal aches
Nonspecific asymmetric, intermittent

Temporal pattern:
Symptoms onset < 4 weeks
Symptoms onset 4-12 weeks
Symptoms onset >12 weeks

Dechallenge:
Improves upon withdrawal (< 2 weeks)
Improves upon withdrawal (2-4 weeks)
Does not improve upon withdrawal (> 4 weeks)

Challenge:
Same symptoms reoccur upon rechallenge < 4 weeks
Same symptoms reoccur upon rechallenge 4-12 weeks




Score Range of points Statin myalgia clinical index score
0 0 0

Determination of the clinical index of statin-associated muscle symptoms

Clinical symptoms (new or increased unexplained muscle symptoms)Points
Regional distribution/pattern 
Symmetric hip flexors/thigh aches3
Symmetric calf aches2
Symmetric upper proximal aches2
Nonspecific asymmetric, intermittent1
Temporal pattern 
Symptoms onset <4 weeks3
Symptoms onset 4-12 weeks2
Symptoms onset >12 weeks1
Dechallenge 
Improves upon withdrawal (<2 weeks)2
Improves upon withdrawal (2-4 weeks)1
Does not improve upon withdrawal (>4 weeks)0
Challenge 
Same symptoms reoccur upon rechallenge <4 weeks3
Same symptoms reoccur upon rechallenge 4-12 weeks1
 
Statin myalgia clinical index score  
Probable9-11
Possible7-8
Unlikely<7

Register on our website right now to have access to more learning materials!

Subscribe to our pages:

Source:
The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI): Revision for Clinical Use, Content Validation, and Inter-rater Reliability.Rosenson RS, Miller K, Bayliss M, Sanchez RJ, Baccara-Dinet MT, Chibedi-De-Roche D, Taylor B, Khan I, Manvelian G, White M, Jacobson TA.Cardiovasc Drugs Ther. 2017 Apr;31(2):179-186. doi: 10.1007/s10557-017-6723-4.PMID: 28421332

Alzheimer disease, Alzheimer, manifestations of Alzheimer's disease, diagnosis of Alzheimer's disease, what is Alzheimer disease, features of Alzheimer's disease, pathology of Alzheimer disease, Alzheimer disease in Down syndrome, treatment of Alzheimer disease, Clinical presentation of Alzheimer disease, dementia, dementia diagnosis, Vascular dementia, Frontotemporal dementia, Pick disease, Creutzfeldt-Jakob disease, Huntington disease

Clinical Presentation Alzheimer Disease

Learning Objectives: 1. Discuss the differential diagnoses of dementia 2. Identify the clinical manifestations of Alzheimer disease 3. Discuss the diagnosis of Alzheimer disease 4. Describe the …
Read More
Share:

Related Articles