The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI)

Symmetric hip flexors or thigh aches
Symmetric calf aches
Symmetric upper proximal aches
Nonspecific asymmetric, intermittent
Symptoms onset < 4 weeks
Symptoms onset 4-12 weeks
Symptoms onset >12 weeks
Improves upon withdrawal (< 2 weeks)
Improves upon withdrawal (2-4 weeks)
Does not improve upon withdrawal (> 4 weeks)
Same symptoms reoccur upon rechallenge < 4 weeks
Same symptoms reoccur upon rechallenge 4-12 weeks
Score | Range of points | Statin myalgia clinical index score |
---|---|---|
0 | 0 | 0 |
Determination of the clinical index of statin-associated muscle symptoms
Clinical symptoms (new or increased unexplained muscle symptoms) | Points |
Regional distribution/pattern | |
Symmetric hip flexors/thigh aches | 3 |
Symmetric calf aches | 2 |
Symmetric upper proximal aches | 2 |
Nonspecific asymmetric, intermittent | 1 |
Temporal pattern | |
Symptoms onset <4 weeks | 3 |
Symptoms onset 4-12 weeks | 2 |
Symptoms onset >12 weeks | 1 |
Dechallenge | |
Improves upon withdrawal (<2 weeks) | 2 |
Improves upon withdrawal (2-4 weeks) | 1 |
Does not improve upon withdrawal (>4 weeks) | 0 |
Challenge | |
Same symptoms reoccur upon rechallenge <4 weeks | 3 |
Same symptoms reoccur upon rechallenge 4-12 weeks | 1 |
Statin myalgia clinical index score | |
Probable | 9-11 |
Possible | 7-8 |
Unlikely | <7 |
Register on our website right now to have access to more learning materials!
Subscribe to our pages:
Source:
The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI): Revision for Clinical Use, Content Validation, and Inter-rater Reliability.Rosenson RS, Miller K, Bayliss M, Sanchez RJ, Baccara-Dinet MT, Chibedi-De-Roche D, Taylor B, Khan I, Manvelian G, White M, Jacobson TA.Cardiovasc Drugs Ther. 2017 Apr;31(2):179-186. doi: 10.1007/s10557-017-6723-4.PMID: 28421332
Clinical Presentation Alzheimer Disease
Learning Objectives: 1. Discuss the differential diagnoses of dementia 2. Identify the clinical manifestations of…
Karnofsky Performance Status Scale Online Calculator
Karnofsky performance status scale determines ability of patient to tolerate chemotherapy. For patients ≥ 16…
Drug Resistance in Pneumonia (DRIP) Score. Online Calculator
The purpose of the DRIP score is to determine when broad-spectrum antibiotics should be used…
Focused Assessment with Sonography for Trauma (FAST): Online Calculator
Focused Assessment with Sonography for Trauma (FAST) predicts the presence of pericardial or intra-abdominal injury…
MELD Score (Model For End-Stage Liver Disease) (12 and older): Online calculator
MELD Score stratifies severity of end-stage liver disease, for transplant planning. NB! MELD Score can…
Maximum Allowable Blood Loss (ABL) Without Transfusion: Online calculator
Maximum Allowable Blood Loss (ABL) Without Transfusion formula can be used in patients with blood…