The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI)
Symmetric hip flexors or thigh aches
Symmetric calf aches
Symmetric upper proximal aches
Nonspecific asymmetric, intermittent
Symptoms onset < 4 weeks
Symptoms onset 4-12 weeks
Symptoms onset >12 weeks
Improves upon withdrawal (< 2 weeks)
Improves upon withdrawal (2-4 weeks)
Does not improve upon withdrawal (> 4 weeks)
Same symptoms reoccur upon rechallenge < 4 weeks
Same symptoms reoccur upon rechallenge 4-12 weeks
| Score | Range of points | Statin myalgia clinical index score |
|---|---|---|
| 0 | 0 | 0 |
Determination of the clinical index of statin-associated muscle symptoms
| Clinical symptoms (new or increased unexplained muscle symptoms) | Points |
| Regional distribution/pattern | |
| Symmetric hip flexors/thigh aches | 3 |
| Symmetric calf aches | 2 |
| Symmetric upper proximal aches | 2 |
| Nonspecific asymmetric, intermittent | 1 |
| Temporal pattern | |
| Symptoms onset <4 weeks | 3 |
| Symptoms onset 4-12 weeks | 2 |
| Symptoms onset >12 weeks | 1 |
| Dechallenge | |
| Improves upon withdrawal (<2 weeks) | 2 |
| Improves upon withdrawal (2-4 weeks) | 1 |
| Does not improve upon withdrawal (>4 weeks) | 0 |
| Challenge | |
| Same symptoms reoccur upon rechallenge <4 weeks | 3 |
| Same symptoms reoccur upon rechallenge 4-12 weeks | 1 |
| Statin myalgia clinical index score | |
| Probable | 9-11 |
| Possible | 7-8 |
| Unlikely | <7 |
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Source:
The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI): Revision for Clinical Use, Content Validation, and Inter-rater Reliability.Rosenson RS, Miller K, Bayliss M, Sanchez RJ, Baccara-Dinet MT, Chibedi-De-Roche D, Taylor B, Khan I, Manvelian G, White M, Jacobson TA.Cardiovasc Drugs Ther. 2017 Apr;31(2):179-186. doi: 10.1007/s10557-017-6723-4.PMID: 28421332
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